Collection: Pharma Development

A313 (Pommade A313) is a French pharmacy retinoid cream that has been loved by dermatologists, makeup artists and beauty insiders for decades. It contains retinyl palmitate and retinyl esters at high concentrations in a nourishing pharmacy-grade Vaseline-and-vitamin-A base. While the retinol esters are technically gentler than pure retinol (requiring two conversion steps to become active retinoic acid in the skin), the high concentration delivers visible anti-aging results: smoother fine lines, brighter tone, improved texture, and increased cell turnover over 8–12 weeks of consistent use.

A313 sits in an unusual middle ground: it's stronger than most over-the-counter retinol creams because of its high concentration, but gentler than prescription tretinoin or retinal-based products because it uses retinyl ester forms that the skin converts more slowly. This makes A313 suitable for users who want noticeable retinoid results without the irritation and peeling of prescription retinoids. The texture is rich and balm-like (Vaseline-based) — different from typical lightweight serum retinols — making it particularly nourishing for dry or mature skin. Available at French pharmacies as an iconic insider product.

Start gradually to avoid irritation. Week 1–2: apply a pea-sized amount to clean dry skin once per week in the evening, followed by a moisturiser. Week 3–4: increase to twice per week. Week 5–8: increase to 3–4 times per week or as tolerated. Long-term: use as tolerated, typically 3–5 nights per week. Always pair with a barrier-supporting moisturiser to buffer dryness, and SPF50+ in the morning since all retinoids increase UV sensitivity. Don't use during the day. Stop use 5–7 days before any aesthetic procedure or laser treatment.

No — all retinoids including retinyl palmitate in A313 are contraindicated during pregnancy and breastfeeding. Studies on oral retinoids have shown teratogenic effects (birth defects), and while topical retinoid absorption is much lower, the medical consensus is to avoid them entirely during pregnancy and lactation as a precaution. If you're trying to conceive, pregnant or breastfeeding, switch to bakuchiol (a plant-based retinol alternative), peptides, or vitamin C for anti-aging benefits. Resume A313 only after weaning.

Yes — A313 can be effective for acne as well as anti-aging. Retinoids in general increase cell turnover, prevent clogged pores, and reduce inflammation — all of which help with acne management. However, A313 is not the first-line choice for active acne — dedicated acne treatments like prescription tretinoin or adapalene are typically more effective for inflammatory breakouts. A313 works best for users dealing with combination concerns: anti-aging plus mild acne, hormonal breakouts, post-acne marks, or sun damage. Pair with a non-comedogenic moisturiser and daily SPF50+.